TNF-α-IN-6

Modify Date: 2025-08-25 18:42:08

TNF-α-IN-6 Structure
TNF-α-IN-6 structure
Common Name TNF-α-IN-6
CAS Number 2699704-20-4 Molecular Weight 495.54
Density N/A Boiling Point N/A
Molecular Formula C26H25N9O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TNF-α-IN-6


TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα (KD = 6.8 nM).

 Names

Name TNF-α-IN-6

 TNF-α-IN-6 Biological Activity

Description TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα (KD = 6.8 nM).
Related Catalog
References

[1]. Dietrich JD, et al. Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design. J Med Chem. 2021 Jan 14;64(1):417-429.

 Chemical & Physical Properties

Molecular Formula C26H25N9O2
Molecular Weight 495.54
InChIKey RUVSMFOFQJDXHE-GOSISDBHSA-N
SMILES CC1(C)C(=O)c2ccc(-c3cnc(N4CCN5C(=O)NCC5C4)nc3)nc2N1Cc1cccnc1C#N
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