Ortho-hydroxy atorvastatin lactone-d5

Modify Date: 2024-01-08 18:03:45

Ortho-hydroxy atorvastatin lactone-d5 Structure
Ortho-hydroxy atorvastatin lactone-d5 structure
Common Name Ortho-hydroxy atorvastatin lactone-d5
CAS Number 265989-50-2 Molecular Weight 561.65
Density N/A Boiling Point N/A
Molecular Formula C33H28D5FN2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ortho-hydroxy atorvastatin lactone-d5


Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

 Names

Name 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide
Synonym More Synonyms

 Ortho-hydroxy atorvastatin lactone-d5 Biological Activity

Description Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.

[3]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

 Chemical & Physical Properties

Molecular Formula C33H28D5FN2O5
Molecular Weight 561.65
Exact Mass 561.26900
PSA 104.28000
LogP 6.88310

 Synonyms

2-Hydroxy Atorvastatin Lactone-d5