265989-45-5

265989-45-5 structure

Name: 4-Hydroxy Atorvastatin-d5 calcium
Chemical Name: calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
CAS Number: 265989-45-5
Molecular Formula: C₃₃H₂₈D₅CaFN₂O₆
Molecular Weight: 617.73
Create Date: 2016-12-27 14:52:15
Modify Date: 2024-01-08 02:15:45

Name	calcium,(3S,5S)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Synonyms	[2H5]-p-Hydroxyatorvastatin calcium salt

Description	4-Hydroxy Atorvastatin-d5 (calcium) 是 4-Hydroxy Atorvastatin氘代物[1]。
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.