Progranulin modulator-1

Modify Date: 2025-08-25 09:57:21

Progranulin modulator-1 structure	Common Name	Progranulin modulator-1
	CAS Number	2641013-11-6	Molecular Weight	369.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₁F₂N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Progranulin modulator-1

Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively[1].

Name	Progranulin modulator-1

Description	Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	EC50: 83 nM (PGRN); IC50: 3100 nM (hERG)
References	[1]. Peng X, et al. Discovery of oxazoline enhancers of cellular progranulin release. Bioorg Med Chem Lett. 2023 Jan 15;80:129048.

Molecular Formula	C₂₁H₂₁F₂N₃O
Molecular Weight	369.41

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Progranulin modulator-1

Use of Progranulin modulator-1

Names

Progranulin modulator-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.