Progranulin modulator-1

Names

[ CAS No. ]:
2641013-11-6

[ Name ]:
Progranulin modulator-1

Biological Activity

[Description]:

Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

EC50: 83 nM (PGRN); IC50: 3100 nM (hERG)


[References]

[1]. Peng X, et al. Discovery of oxazoline enhancers of cellular progranulin release. Bioorg Med Chem Lett. 2023 Jan 15;80:129048.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H21F2N3O

[ Molecular Weight ]:
369.41

Related Compounds

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