USP10 inhibitor Wu-5
Modify Date: 2024-01-05 00:36:32
USP10 inhibitor Wu-5 structure
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Common Name | USP10 inhibitor Wu-5 | ||
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| CAS Number | 2630378-05-9 | Molecular Weight | 351.329 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13NO7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of USP10 inhibitor Wu-5USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells.Wu-5 selectively inhibited the viability of FLT3 inhibitor-sensitive (MV4-11, Molm13) and -resistant (MV4-11R) FLT3-ITD-positive AML cells with IC50 of 3.794, 5.056, and 8.386 uM, respectively.Wu-5 (1-10 μM) dose-dependently induced apoptosis of MV4-11, Molm13, and MV4-11R cells through the proteasome-mediated degradation of FLT3-ITD.Combined treatment of Wu-5 and crenolanib produced synergistic cell death in FLT3-ITD-positive cells via the reduction of both FLT3 and AMPKα proteins. |
| Name | USP10 inhibitor Wu-5 |
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| Description | USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells.Wu-5 selectively inhibited the viability of FLT3 inhibitor-sensitive (MV4-11, Molm13) and -resistant (MV4-11R) FLT3-ITD-positive AML cells with IC50 of 3.794, 5.056, and 8.386 uM, respectively.Wu-5 (1-10 μM) dose-dependently induced apoptosis of MV4-11, Molm13, and MV4-11R cells through the proteasome-mediated degradation of FLT3-ITD.Combined treatment of Wu-5 and crenolanib produced synergistic cell death in FLT3-ITD-positive cells via the reduction of both FLT3 and AMPKα proteins. |
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| References | 1. Miao Yu, et al. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. |
| Molecular Formula | C15H13NO7S |
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| Molecular Weight | 351.329 |