IDH1 Inhibitor 5
Modify Date: 2025-08-27 10:16:22
IDH1 Inhibitor 5 structure
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Common Name | IDH1 Inhibitor 5 | ||
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| CAS Number | 1940128-37-9 | Molecular Weight | 450.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H34N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IDH1 Inhibitor 5IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1]. |
| Name | IDH1 Inhibitor 5 |
|---|
| Description | IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1] |
| In Vitro | IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein Concentration: 0-10 μM Incubation Time: 1 hour Result: Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively. |
| References |
| Molecular Formula | C26H34N4O3 |
|---|---|
| Molecular Weight | 450.57 |
| InChIKey | FFJIUZWEHCMKKS-UHFFFAOYSA-N |
| SMILES | CC(C)OC1CCC(C(=O)N2Cc3cccnc3Nc3ccc(N4CCOCC4)cc32)CC1 |