CP-532623
Modify Date: 2025-08-24 21:31:14
CP-532623 structure
|
Common Name | CP-532623 | ||
|---|---|---|---|---|
| CAS Number | 261947-38-0 | Molecular Weight | 598.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H27F9N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CP-532623CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3]. |
| Name | CP-532623 |
|---|
| Description | CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CETP[1] |
| In Vitro | CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons[2]. |
| In Vivo | CP-532623 (50 mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623[3]. Animal Model: Adult male greyhound dogs (27-39 kg)[3] Dosage: 50 mg Administration: Oral administration with a long-chain lipid formulation to fed lymphcannulated Result: Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph. |
| References |
| Molecular Formula | C27H27F9N2O3 |
|---|---|
| Molecular Weight | 598.50 |
| InChIKey | TUPKOWFPVAXQFP-OFNKIYASSA-N |
| SMILES | CCC1CC(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(C)=O)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C |
| Storage condition | 2-8°C |