Antibacterial agent 89

Modify Date: 2024-01-01 17:43:38

Antibacterial agent 89 structure	Common Name	Antibacterial agent 89
	CAS Number	2589639-87-0	Molecular Weight	516.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₀Cl₂F₃NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antibacterial agent 89

Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription[1].

Name	Antibacterial agent 89

Description	Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 µg/mL, respectively[1]. Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 µg/mL[1]. Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027[1]. Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 µM[1]. Antibacterial agent 89 (1, 2, 4 µg/mL; B. subtilis) alters the localization of bacterial transcription complexes[1]. Antibacterial agent 89 (0.5, 0.25 µg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells[1]. Western Blot Analysis[1] Cell Line: S. aureus ATCC 29213 cells Concentration: 0.5, 0.25 µg/mL Incubation Time: Result: Reduced the total levels of protein observed in S. aureus ATCC 29213 cells.
References	[1]. Ye J, et al. Benzyl and benzoyl benzoic acid inhibitors of bacterial RNA polymerase-sigma factor interaction. Eur J Med Chem. 2020 Dec 15;208:112671.

Molecular Formula	C₂₁H₁₀Cl₂F₃NO₅S
Molecular Weight	516.27

Antibacterial agent 89

Use of Antibacterial agent 89

Names

Antibacterial agent 89 Biological Activity

Chemical & Physical Properties