| In Vitro |
Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 µg/mL, respectively[1]. Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 µg/mL[1]. Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027[1]. Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 µM[1]. Antibacterial agent 89 (1, 2, 4 µg/mL; B. subtilis) alters the localization of bacterial transcription complexes[1]. Antibacterial agent 89 (0.5, 0.25 µg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells[1]. Western Blot Analysis[1] Cell Line: S. aureus ATCC 29213 cells Concentration: 0.5, 0.25 µg/mL Incubation Time: Result: Reduced the total levels of protein observed in S. aureus ATCC 29213 cells.
|
