Dot1L-IN-7

Modify Date: 2025-08-24 07:04:02

Dot1L-IN-7 structure	Common Name	Dot1L-IN-7
	CAS Number	2580940-76-5	Molecular Weight	461.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₇N₉O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dot1L-IN-7

Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].

Name	Dot1L-IN-7

Description	Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	DOT1L:1 μM (IC50)
References	[1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.

Molecular Formula	C₂₃H₂₇N₉O₂
Molecular Weight	461.52

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Dot1L-IN-7

Use of Dot1L-IN-7

Names

Dot1L-IN-7 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.