2,2,6,6-Tetramethylpiperidinooxy

Modify Date: 2024-01-02 17:42:01

2,2,6,6-Tetramethylpiperidinooxy structure	Common Name	2,2,6,6-Tetramethylpiperidinooxy
	CAS Number	2564-83-2	Molecular Weight	156.245
	Density	1 g/cm3	Boiling Point	193°C
	Molecular Formula	C₁₀H₂₁NO?	Melting Point	36-38 °C(lit.)
	MSDS	Chinese USA	Flash Point	154 °F
	Symbol	GHS05	Signal Word	Danger

Use of 2,2,6,6-Tetramethylpiperidinooxy

Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].

Name	tempo
Synonym	More Synonyms

Description	Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
References	[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

References

[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773.

[2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225.

[3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22.

[4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

Density	1 g/cm3
Boiling Point	193°C
Melting Point	36-38 °C(lit.)
Molecular Formula	C₁₀H₂₁NO?
Molecular Weight	156.245
Flash Point	154 °F
Exact Mass	156.138840
PSA	3.24000
LogP	2.31290
Storage condition	2-8°C
Stability	Stable. Incompatible with strong acids, strong oxidizing agents. Refrigerate.

2,2,6,6-Tetramethylpiperidinooxy MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN8991900

CHEMICAL NAME :: Piperidinooxy, 2,2,6,6-tetramethyl-

CAS REGISTRY NUMBER :: 2564-83-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H18-N-O

MOLECULAR WEIGHT :: 156.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive; Xi:Irritant
Risk Phrases	R34;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S24/25
RIDADR	UN 3263 8/PG 2
WGK Germany	3
RTECS	TN8991900
Packaging Group	III
Hazard Class	8
HS Code	29333999

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HS Code	29333999

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Tanan

2,6,6-Tetramethylpiperidine N-oxide

2,2,6,6-Tetramethyl piperidine-N-oxyl

(2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl

2,2,6,6-tetramethyl-1-piperidinyloxy radical

2,2,6,6-Tetramethylpiperidoxyl

free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl

2,2,6,6-Tetramethyl-1-piperidinyloxy

2,2,6,6-Tetramethylpiperidine 1-Oxyl Free Radical

1-Piperidinyloxy, 2,2,6,6-tetramethyl-

Piperidinooxy, 2,2,6,6-tetramethyl-

2,2,6,6-Tetramethylpiperidinooxy

Tetramethylpiperidinooxy

T6NTJ AO B1 B1 F1 F1 &&Free Radical

Tanane

tetramethylpiperidinenitroxide

EINECS 219-888-8

(2,2,6,6-Tetramethylpiperidin-1-yl)oxidanyl

TEMPO

2,2,6,6-tetramethylperidinooxy

2,2,6,6-tetramethyl-1-piperidinyloxy,free radical

MFCD00009599

2,2,6,6-Tetramethyl-1-piperidinyloxy,free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2,2,6,6-Tetramethylpiperidinooxy
Price: ￥108.0/25g ￥308.0/100g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: AI3-51508
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2,6,6-Tetramethylpiperidinooxy
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2,2,6,6-Tetramethylpiperidinooxy
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TEMPO
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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2,2,6,6-Tetramethylpiperidinooxy

Use of 2,2,6,6-Tetramethylpiperidinooxy

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