2564-83-2

2564-83-2 structure

Name: 2,2,6,6-Tetramethylpiperidinooxy
Chemical Name: tempo
CAS Number: 2564-83-2
Molecular Formula: C₁₀H₂₁NO?
Molecular Weight: 156.245
Catalog: Organic raw materials Heterocyclic compound
Create Date: 2019-01-01 21:59:17
Modify Date: 2025-08-21 23:50:37
Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].

Name	tempo
Synonyms	Tanan 2,6,6-Tetramethylpiperidine N-oxide 2,2,6,6-Tetramethyl piperidine-N-oxyl (2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl 2,2,6,6-tetramethyl-1-piperidinyloxy radical 2,2,6,6-Tetramethylpiperidoxyl free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl 2,2,6,6-Tetramethyl-1-piperidinyloxy 2,2,6,6-Tetramethylpiperidine 1-Oxyl Free Radical 1-Piperidinyloxy, 2,2,6,6-tetramethyl- Piperidinooxy, 2,2,6,6-tetramethyl- 2,2,6,6-Tetramethylpiperidinooxy Tetramethylpiperidinooxy T6NTJ AO B1 B1 F1 F1 &&Free Radical Tanane tetramethylpiperidinenitroxide EINECS 219-888-8 (2,2,6,6-Tetramethylpiperidin-1-yl)oxidanyl TEMPO 2,2,6,6-tetramethylperidinooxy 2,2,6,6-tetramethyl-1-piperidinyloxy,free radical MFCD00009599 2,2,6,6-Tetramethyl-1-piperidinyloxy,free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl

Description	Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
References	[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

Density	1 g/cm3
Boiling Point	193°C
Melting Point	36-38 °C(lit.)
Molecular Formula	C₁₀H₂₁NO?
Molecular Weight	156.245
Flash Point	154 °F
Exact Mass	156.138840
PSA	3.24000
LogP	2.31290
Storage condition	2-8°C
Stability	Stable. Incompatible with strong acids, strong oxidizing agents. Refrigerate.

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S ** ACUTE TOXICITY DATA **

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive; Xi:Irritant
Risk Phrases	R34;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S24/25
RIDADR	UN 3263 8/PG 2
WGK Germany	3
RTECS	TN8991900
Packaging Group	III
Hazard Class	8
HS Code	29333999

HS Code	29333999