Demethyleneberberine

Modify Date: 2025-08-20 16:41:06

Demethyleneberberine structure	Common Name	Demethyleneberberine
	CAS Number	25459-91-0	Molecular Weight	323.34300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₈NO₄+	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Demethyleneberberine

Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD)[1][2][3].

Name	9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
Synonym	More Synonyms

Description	Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD)[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Inflammation/Immunology Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
References	[1]. Zhang P, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47. [2]. Chen YY, et al. Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196. [3]. Qiang X, et al. Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> AMPK

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

Research Areas >> Metabolic Disease

References

[1]. Zhang P, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47.

[2]. Chen YY, et al. Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196.

[3]. Qiang X, et al. Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.

Molecular Formula	C₁₉H₁₈NO₄+
Molecular Weight	323.34300
Exact Mass	323.11600
PSA	59.64000
LogP	1.64990
InChIKey	HVTCKKMWZDDWOY-UHFFFAOYSA-O
SMILES	COc1ccc2cc3[n+](cc2c1OC)CCc1cc(O)c(O)cc1-3

Berberine hydro...

CAS#:633-65-8

~43%

Demethyleneberberine

CAS#:25459-91-0

Literature: XINTRIA PHARMACEUTICAL CORPORATION, INC.; LIPPA, Arnold, Stan Patent: WO2010/104595 A1, 2010 ; Location in patent: Page/Page column 103 ;

dopamine

CAS#:51-61-6

Demethyleneberberine

CAS#:25459-91-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

2,3-Dimethoxybe...

CAS#:86-51-1

Demethyleneberberine

CAS#:25459-91-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 - 1383

Precursor 3
CAS#:633-65-8 Berberine hydro... CAS#:51-61-6 dopamine CAS#:86-51-1 2,3-Dimethoxybe...
DownStream 0

demethyleneberberine

2,3-Dihydroxy-9,10-dimethoxy-7,8,13,14-tetradehydro-berbinium

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium

7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-dihydroxy-berbinium

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium

Demethylen-berberin

Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3-dihydroxy-9,10-dimethoxy

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Demethyleneberberine
Price: Check
Purity: 96.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Demethyleneberberine
Price: ￥1388.0/10mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Demethyleneberberine
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DeMethyleneberberine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Demethyleneberberine

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