tesaglitazar

Modify Date: 2024-01-04 01:50:03

tesaglitazar Structure
tesaglitazar structure
 Common Name tesaglitazar
CAS Number 251565-85-2 Molecular Weight 408.465
Density 1.3±0.1 g/cm3 Boiling Point 611.3±55.0 °C at 760 mmHg
Molecular Formula C20H24O7S Melting Point N/A
MSDS Chinese USA Flash Point 323.5±31.5 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of tesaglitazar


Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].

 Names

Name (2S)-2-ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl]propanoic acid
Synonym More Synonyms

 tesaglitazar Biological Activity

Description Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
Related Catalog
Target

EC50: 13.4 μM (rat PPARα), 3.6 μM (human PPARα), 0.2 μM (PPARγ)[1]

References

[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 611.3±55.0 °C at 760 mmHg
Molecular Formula C20H24O7S
Molecular Weight 408.465
Flash Point 323.5±31.5 °C
Exact Mass 408.124268
PSA 107.51000
LogP 2.64
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.566
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport
HS Code 2918990090

 Synthetic Route

1,4-Dioxane structure

1,4-Dioxane

CAS#:123-91-1

(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)-3-[4-(2-{4-methanesulfonyloxyphenyl}-ethoxy)phenyl]propanoic amide structure

(S)-2-ethoxy-N-...

CAS#:251565-89-6

Heptane structure

Heptane

CAS#:142-82-5

~80%

tesaglitazar Structure

tesaglitazar

CAS#:251565-85-2

Literature: AstraZeneca AB Patent: US6258850 B1, 2001 ;
ethyl (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoate structure

ethyl (2S)-2-et...

CAS#:251565-91-0

~%

tesaglitazar Structure

tesaglitazar

CAS#:251565-85-2

Literature: WO2003/82812 A2, ; Page/Page column 6 ; WO 03/082812 A2

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

[14C]-Tesaglitazar
Benzenepropanoic acid, α-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-, (αS)-
(2S)-2-Ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid
Galida
tesaglitazar
(S)-2-ethoxy-3-[4-(2-{4-methanesulfonyloxy-phenyl}ethoxy)phenyl]propanoic acid
AZ-242
(S)-2-Ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl}propionic acid
(S)-2-ethoxy-3-[4-(2-{4-methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid
(2S)-2-ethoxy-3-[4-(2-{4-[(methylsuIfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid
AZ2
(2S)-2-Ethoxy-3-[4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]phenyl]propanoic acid
(S)-2-ethoxy-3-(4-(2-(4-methylsulphonyloxyphenyl)ethoxy)phenyl)propanoic acid
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Related Compounds: More...
TESAGLITAZAR
251565-88-5
Chemsrc provides tesaglitazar(CAS#:251565-85-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of tesaglitazar are included as well.>> amp version: tesaglitazar

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