Heptane

Modify Date: 2024-01-02 20:00:08

Heptane Structure
Heptane structure
Common Name Heptane
CAS Number 142-82-5 Molecular Weight 100.202
Density 0.683 Boiling Point 98.8±3.0 °C at 760 mmHg
Molecular Formula C7H16 Melting Point −91 °C(lit.)
MSDS Chinese USA Flash Point -1.1±0.0 °C
Symbol GHS02 GHS07 GHS08 GHS09
GHS02, GHS07, GHS08, GHS09
Signal Word Danger

 Names

Name Heptane
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.683
Boiling Point 98.8±3.0 °C at 760 mmHg
Melting Point −91 °C(lit.)
Molecular Formula C7H16
Molecular Weight 100.202
Flash Point -1.1±0.0 °C
Exact Mass 100.125198
LogP 4.47
Vapour density 3.5 (vs air)
Vapour Pressure 45.2±0.1 mmHg at 25°C
Index of Refraction 1.394
Stability Stable. Incompatible with oxidizing agents, chlorine, phosphorus. Highly flammable. Readily forms explosive mixtures with air.
Water Solubility practically insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MI7700000
CHEMICAL NAME :
Heptane
CAS REGISTRY NUMBER :
142-82-5
LAST UPDATED :
199712
DATA ITEMS CITED :
42
MOLECULAR FORMULA :
C7-H16
MOLECULAR WEIGHT :
100.23
WISWESSER LINE NOTATION :
7H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
1000 ppm/6M
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
BMRII* "U.S. Bureau of Mines Report of Investigation No. 2979," Patty, F.A., and W.P. Yant, 1929 Volume(issue)/page/year: 2979,-,1929
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
103 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(10),23,1988
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59 gm/m3/41M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 115,235,1921
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
222 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,566,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 gm/kg/3W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571116
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
260 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Endocrine - hypoglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571116
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 ppm/6H/28D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 76,41,1995
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9625 mg/kg/7D-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 14,169,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8840 mg/kg/45D-I
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 8,81,1988 *** REVIEWS *** ACGIH TLV-STEL 2050 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1640 mg/m3 (400 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 500 ppm (2000 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,124,1971 OSHA PEL (Gen Indu):8H TWA 500 ppm (2000 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 500 ppm (2000 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 500 ppm (2000 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 500 ppm (2000 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 400 ppm (1600 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 1993 OEL-BELGIUM:TWA 400 ppm (1640 mg/m3);STEL 500 ppm (2050 mg/m3) JAN 1993 OEL-DENMARK:TWA 400 ppm (1600 mg/m3) JAN 1993 OEL-FINLAND:TWA 300 ppm (1200 mg/m3);STEL 500 ppm (2000 mg/m3) JAN 1993 OEL-FRANCE:TWA 400 ppm (1600 mg/m3) JAN 1993 OEL-GERMANY:TWA 500 ppm (2000 mg/m3) JAN 1993 OEL-JAPAN:TWA 200 ppm (820 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 400 ppm (1600 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 500 ppm (2000 mg/m3) JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 200 ppm JAN 1993 OEL-SWEDEN:TWA 200 ppm (800 mg/m3);STEL 300 ppm (1250 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 400 ppm (1600 mg/m3);STEL 800 ppm JAN 1993 OEL-TURKEY:TWA 500 ppm (2000 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 400 ppm (1600 mg/m3);STEL 500 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HEPTANE-air:10H TWA 85 ppm;CL 440 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 36060 No. of Facilities: 20154 (estimated) No. of Industries: 153 No. of Occupations: 110 No. of Employees: 221101 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 36060 No. of Facilities: 37852 (estimated) No. of Industries: 191 No. of Occupations: 134 No. of Employees: 449487 (estimated) No. of Female Employees: 44550 (estimated)

 Safety Information

Symbol GHS02 GHS07 GHS08 GHS09
GHS02, GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H225-H304-H315-H336-H410
Precautionary Statements P210-P261-P273-P301 + P310-P331-P501
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable
Risk Phrases R11;R38;R50/53;R65;R67
Safety Phrases S9-S16-S29-S33-S60-S61-S62-S23
RIDADR UN 1206 3/PG 2
WGK Germany 3
RTECS MI7700000
Packaging Group II
Hazard Class 3
HS Code 2901100000

 Synthetic Route

 Customs

HS Code 2901100000
Summary 2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

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 Synonyms

1-HEPTANE
EINECS 205-563-8
n-heptane
ethyl-pentane
n-C7H16
Heptane
Eptani
anhydrous n-heptane
Heptan
ALKANE C7
MFCD00009544
HEPTANE-200
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