Rutoside Trihydrate

Modify Date: 2025-08-21 08:43:34

Rutoside Trihydrate structure	Common Name	Rutoside Trihydrate
	CAS Number	250249-75-3	Molecular Weight	324.49800
	Density	1.82g/cm3	Boiling Point	983.1ºC at 760mmHg
	Molecular Formula	C₂₀H₃₆O₃	Melting Point	195ºC
	MSDS	Chinese USA	Flash Point	325.4ºC
	Symbol	GHS07	Signal Word	Warning

Use of Rutoside Trihydrate

Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].

Name	Rutin trihydrate
Synonym	More Synonyms

Description	Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Rutin (Rutoside) trihydrate (0.5- 160 μM/ml; PC12 cells) decreases the acrylamide (ACR)-induced (5.46 mM) cytotoxicity significantly. ACR (5.46 mM) decreases cell viability in PC12 cells and pretreatment with rutin (0.5, 1, 1.5, 2.5, 5, 10, 20 and 40 μM/ml) increases the cell viability[2]. Due to the ability of Rutin and/or its metabolites to cross the blood brain barrier, it has also been shown to modify the cognitive and various behavioral symptoms of neurodegenerative diseases[3].
In Vivo	Pretreatment of Rutin (100 and 200 mg/kg/day; i.p.) for long-term caused behavioural and neurochemical changes in aged WAG male rats[2].
References	[1]. Mel MMRD, et al. Formulation of microencapsulated rutin and evaluation of bioactivity and stability upon in vitro digestive and dialysis conditions. Int J Biol Macromol. 2020;159:316-323. [2]. Doostkam A, et al. Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model. Clin Exp Otorhinolaryngol. 2021;14(3):259-267. [3]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

Density	1.82g/cm3
Boiling Point	983.1ºC at 760mmHg
Melting Point	195ºC
Molecular Formula	C₂₀H₃₆O₃
Molecular Weight	324.49800
Flash Point	325.4ºC
Exact Mass	324.26600
PSA	27.69000
LogP	6.34500
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.764
InChIKey	NLLBWFFSGHKUSY-JPRRWYCFSA-N
SMILES	CC1OC(OCC2OC(Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)C(O)C(O)C2O)C(O)C(O)C1O.O.O.O

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.

Indian J. Exp. Biol. 52(10) , 965-71, (2014)

In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory ac...

Ruminal degradation of quercetin and its influence on fermentation in ruminants.

J. Dairy Sci. 98 , 5688-98, (2015)

The aim of the present study was to investigate the ruminal degradation of the flavonol quercetin and to determine its potential antimicrobial effects on ruminal fermentation in cows. Ruminal degradat...

Rutoside trihydrate

MFCD00149490

EINECS 205-814-1

Quercetin-3-rutinoside trihydrate,Vitamin P trihydrate