Rutoside Trihydrate

Names

[ Name ]:
Rutoside Trihydrate

[Synonym ]:
Rutoside trihydrate
MFCD00149490
EINECS 205-814-1
Quercetin-3-rutinoside trihydrate,Vitamin P trihydrate

Biological Activity

[Description]:

Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Rutin (Rutoside) trihydrate (0.5- 160 μM/ml; PC12 cells) decreases the acrylamide (ACR)-induced (5.46 mM) cytotoxicity significantly. ACR (5.46 mM) decreases cell viability in PC12 cells and pretreatment with rutin (0.5, 1, 1.5, 2.5, 5, 10, 20 and 40 μM/ml) increases the cell viability[2]. Due to the ability of Rutin and/or its metabolites to cross the blood brain barrier, it has also been shown to modify the cognitive and various behavioral symptoms of neurodegenerative diseases[3].

[In Vivo]

Pretreatment of Rutin (100 and 200 mg/kg/day; i.p.) for long-term caused behavioural and neurochemical changes in aged WAG male rats[2].

[References]

[1]. Mel MMRD, et al. Formulation of microencapsulated rutin and evaluation of bioactivity and stability upon in vitro digestive and dialysis conditions. Int J Biol Macromol. 2020;159:316-323.

[2]. Doostkam A, et al. Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model. Clin Exp Otorhinolaryngol. 2021;14(3):259-267.

[3]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

Chemical & Physical Properties

[ Density]:
1.82g/cm3

[ Boiling Point ]:
983.1ºC at 760mmHg

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C₂₀H₃₆O₃

[ Molecular Weight ]:
324.49800

[ Flash Point ]:
325.4ºC

[ Exact Mass ]:
324.26600

[ PSA ]:
27.69000

[ LogP ]:
6.34500

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.764

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo.

Indian J. Exp. Biol. 52(10) , 965-71, (2014)

In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory ac...

Ruminal degradation of quercetin and its influence on fermentation in ruminants.

J. Dairy Sci. 98 , 5688-98, (2015)

The aim of the present study was to investigate the ruminal degradation of the flavonol quercetin and to determine its potential antimicrobial effects on ruminal fermentation in cows. Ruminal degradat...