4-Aminobenzamidine dihydrochloride

Modify Date: 2025-08-23 20:25:38

4-Aminobenzamidine dihydrochloride structure	Common Name	4-Aminobenzamidine dihydrochloride
	CAS Number	2498-50-2	Molecular Weight	208.088
	Density	1.26g/cm3	Boiling Point	289.8ºC at 760 mmHg
	Molecular Formula	C₇H₁₁Cl₂N₃	Melting Point	>300 °C(lit.)
	MSDS	USA	Flash Point	129ºC

Use of 4-Aminobenzamidine dihydrochloride

4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice[1][2].

Name	4-aminobenzenecarboximidamide,dihydrochloride
Synonym	More Synonyms

Description	4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	Trypsin[1] Ki: 82 μM (uPA)[1]
References	[1]. Nguyen AL, et al. The development and application of a new affinity partitioning system for enzyme isolation and purification. Enzyme Microb Technol. 1990 Sep;12(9):663-8. [2]. Billström A, et al. The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice. Int J Cancer. 1995 May 16;61(4):542-7.

Density	1.26g/cm3
Boiling Point	289.8ºC at 760 mmHg
Melting Point	>300 °C(lit.)
Molecular Formula	C₇H₁₁Cl₂N₃
Molecular Weight	208.088
Flash Point	129ºC
Exact Mass	207.033005
PSA	75.89000
LogP	3.53810
Vapour Pressure	0.00216mmHg at 25°C
InChIKey	GHEHNICLPWTXJC-UHFFFAOYSA-N
SMILES	Cl.Cl.N=C(N)c1ccc(N)cc1
Storage condition	2-8°C

4-Aminobenzamidine dihydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6126500

CHEMICAL NAME :: Benzamidine, p-amino-, dihydrochloride

CAS REGISTRY NUMBER :: 2498-50-2

LAST UPDATED :: 199007

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-N3.2Cl-H

MOLECULAR WEIGHT :: 208.11

WISWESSER LINE NOTATION :: ZR DYZUM &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CV6126500

4-Aminobenzonitrile

CAS#:873-74-5

4-Aminobenzamid...

CAS#:2498-50-2

Literature: US2014/114089 A1, ;

Precursor 1
CAS#:873-74-5 4-Aminobenzonitrile
DownStream 5
CAS#:873-74-5 4-Aminobenzonitrile CAS#:872728-81-9 Dabigatran etex... CAS#:149820-74-6 ethyl (3S)-3-[[... CAS#:832075-85-1 4-(4-methylsulf...
CAS#:832075-88-4 4-(4-methylsulf...

Comparative study on the inhibition of plasmin and delta-plasmin via benzamidine derivatives.

Biochem. Biophys. Res. Commun. 457(3) , 358-62, (2015)

The potent fibrinolytic enzyme, plasmin has numerous clinical applications for recannulizing vessels obstructed by thrombus. Despite its diminutive size, 91 kDa, success in the recombinant expression ...

p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.

J. Biol. Chem. 257 , 3014, (1982)

p-Aminobenzamidine is weakly fluorescent in neutral aqueous buffer, with excitation and emission maxima at 293 and 376 nm, respectively. Binding to trypsin results in a blue shift of the emission peak...

Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine.

Eur. J. Biochem. 6 , 502, (1968)

4-AMBA dihydrochloride

Benzenecarboximidamide, 4-amino-, hydrochloride (1:2)

4-aminobenzimidamide dihydrochloride

4-aminobenzimidine dihydrochloride

MFCD00013001

4-aminobenzoamidine dihydrochloride

P-AMINOBENZAMIDINE DIHCL

4-AMINOBENZAMIDINE 2HCL

Benzenecarboximidamide,4-amino-,dihydrochloride

4-Aminobenzenecarboximidamide dihydrochloride

p-Aminobenzamidine dihydrochloride

Benzamidine,p-amino-,dihydrochloride

EINECS 219-692-2

4-Aminobenzamidine Dihydrochloride

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Aminobenzamidine dihydrochloride
Price: Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Aminobenzamidine dihydrochloride
Price: ￥118.0/1g ￥368.0/5g
Purity: 97.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Aminobenzamidine dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-aminobenzenecarboximidamide,dihydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 4-Aminobenzamidine dihydrochloride
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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