CDK8-IN-10

Modify Date: 2025-11-25 15:58:21

CDK8-IN-10 structure	Common Name	CDK8-IN-10
	CAS Number	2457317-40-5	Molecular Weight	525.87
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₁₅ClF₃N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK8-IN-10

CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].

Name	CDK8-IN-10

Description	CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK8:8.25 nM (IC50)
In Vitro	CDK8-IN-10 (compound 2; 8 h; SW620 cells) reduces phosphorylation of CDK8 substrate STAT1 in cells with an IC50 value of 1.3 µM[1].
References	[1]. Martínez-González S, et, al. Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur J Med Chem. 2020 Sep 1;201:112443.

Molecular Formula	C₂₅H₁₅ClF₃N₅O₃
Molecular Weight	525.87

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