1629633-48-2
1629633-48-2 structure
- Name: CDK8-IN-1
- Chemical Name: CDK8-IN-1
- CAS Number: 1629633-48-2
- Molecular Formula: C11H8F3N3O
- Molecular Weight: 255.20
- Catalog: Research Areas Cancer
- Create Date: 2019-02-11 21:36:03
- Modify Date: 2023-01-31 13:44:32
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CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
| Name | CDK8-IN-1 |
|---|
| Description | CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. |
|---|---|
| Related Catalog | |
| Target |
CDK8:3 nM (IC50) |
| In Vivo | CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1]. |
| Animal Admin | Mice[1] CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1]. |
| References |
| Molecular Formula | C11H8F3N3O |
|---|---|
| Molecular Weight | 255.20 |