2415156-27-1

2415156-27-1 structure

Name: CDK8-IN-6
Chemical Name: CDK8-IN-6
CAS Number: 2415156-27-1
Molecular Formula: C₂₆H₃₇ClN₂
Molecular Weight: 413.04
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-08-07 08:48:26
Modify Date: 2023-01-11 21:22:08
CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer[1].

Name	CDK8-IN-6

Description	CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK8:13 nM (Kd)
References	[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.

Molecular Formula	C₂₆H₃₇ClN₂
Molecular Weight	413.04