G6PDi-1

Modify Date: 2025-08-25 15:40:19

G6PDi-1 Structure
G6PDi-1 structure
 Common Name G6PDi-1
CAS Number 2457232-14-1 Molecular Weight 284.34
Density 1.4±0.1 g/cm3 Boiling Point 527.6±60.0 °C at 760 mmHg
Molecular Formula C14H12N4OS Melting Point N/A
MSDS N/A Flash Point 272.9±32.9 °C

 Use of G6PDi-1


G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1].

 Names

Name G6PDi-1
Synonym More Synonyms

 G6PDi-1 Biological Activity

Description G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1].
Related Catalog
References

[1]. Jonathan M Ghergurovich, et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 Jul;16(7):731-739.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 527.6±60.0 °C at 760 mmHg
Molecular Formula C14H12N4OS
Molecular Weight 284.34
Flash Point 272.9±32.9 °C
Exact Mass 284.073181
LogP 2.51
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.658

 Safety Information

Hazard Codes Xi

 Synonyms

4-[(5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino]-2-thiophenecarbonitrile
G6PDi-1
2-Thiophenecarbonitrile, 4-[(6,7,8,9-tetrahydro-5-oxo-5H-cyclohepta[d]pyrimidin-2-yl)amino]-
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Chemsrc provides G6PDi-1(CAS#:2457232-14-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of G6PDi-1 are included as well.>> amp version: G6PDi-1

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