G6PDi-1

Names

[ Name ]:
G6PDi-1

[Synonym ]:
4-[(5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino]-2-thiophenecarbonitrile
G6PDi-1
2-Thiophenecarbonitrile, 4-[(6,7,8,9-tetrahydro-5-oxo-5H-cyclohepta[d]pyrimidin-2-yl)amino]-

Biological Activity

[Description]:

G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[References]

[1]. Jonathan M Ghergurovich, et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 Jul;16(7):731-739.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
527.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂N₄OS

[ Molecular Weight ]:
284.34

[ Flash Point ]:
272.9±32.9 °C

[ Exact Mass ]:
284.073181

[ LogP ]:
2.51

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.658

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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