CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
NX4912700
-
CHEMICAL NAME :
-
Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-
-
CAS REGISTRY NUMBER :
-
24526-64-5
-
LAST UPDATED :
-
199512
-
DATA ITEMS CITED :
-
6
-
MOLECULAR FORMULA :
-
C16-H18-N2
-
MOLECULAR WEIGHT :
-
238.36
-
WISWESSER LINE NOTATION :
-
T66 CNT&J C1 ER& JZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
7 mg/kg/7D-I
-
TOXIC EFFECTS :
-
Blood - hemorrhage Blood - thrombocytopenia
-
REFERENCE :
-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
500 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold
-
REFERENCE :
-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
260 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Behavioral - aggression
-
REFERENCE :
-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
128 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
264 mg/kg
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - other changes
-
REFERENCE :
-
DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA **
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
4 mg/kg
-
SEX/DURATION :
-
lactating female 1 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - other effects
-
REFERENCE :
-
GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987
|