ND-011992

Modify Date: 2024-01-02 23:22:31

ND-011992 Structure
ND-011992 structure
Common Name ND-011992
CAS Number 2446880-46-0 Molecular Weight 381.35
Density N/A Boiling Point N/A
Molecular Formula C21H14F3N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ND-011992


ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].

 Names

Name ND-011992

 ND-011992 Biological Activity

Description ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].
Related Catalog
Target

0.12 μM (respiratory complex I), 2.47 (bo3 oxidase), 0.63 (bd-I oxidases), 1.3 (bd-II oxidases)

References

[1]. Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w  

 Chemical & Physical Properties

Molecular Formula C21H14F3N3O
Molecular Weight 381.35
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