ND-011992

Names

[ Name ]:
ND-011992

Biological Activity

[Description]:

ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

0.12 μM (respiratory complex I), 2.47 (bo3 oxidase), 0.63 (bd-I oxidases), 1.3 (bd-II oxidases)

[References]

[1]. Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₄F₃N₃O

[ Molecular Weight ]:
381.35

Related Compounds

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