Tectol

Modify Date: 2024-01-10 06:58:54

Tectol structure	Common Name	Tectol
	CAS Number	24449-39-6	Molecular Weight	450.52500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tectol

Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

Name	tectol
Synonym	More Synonyms

Description	Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
References	[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795. [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

References

[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795.

[2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.

Molecular Formula	C₃₀H₂₆O₄
Molecular Weight	450.52500
Exact Mass	450.18300
PSA	58.92000
LogP	7.43960

Hazard Codes	Xi

2,2,2',2'-tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol

Tectol

2,2,2',2'-Tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol

DC Chemicals Limited
China
Product Name: Tectol
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Tectol

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