Tectol

Names

[ Name ]:
Tectol

[Synonym ]:
2,2,2',2'-tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol
Tectol
2,2,2',2'-Tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol

Biological Activity

[Description]:

Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

[References]

[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795.

[2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₆O₄

[ Molecular Weight ]:
450.52500

[ Exact Mass ]:
450.18300

[ PSA ]:
58.92000

[ LogP ]:
7.43960

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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