24449-39-6

24449-39-6 structure

Name: Tectol
Chemical Name: tectol
CAS Number: 24449-39-6
Molecular Formula: C₃₀H₂₆O₄
Molecular Weight: 450.52500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Farnesyl Transferase
Create Date: 2018-01-16 13:24:26
Modify Date: 2024-01-10 06:58:54
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

Name	tectol
Synonyms	2,2,2',2'-tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol Tectol 2,2,2',2'-Tetramethyl-2H,2'H-[5,5']bi[benzo[h]chromenyl]-6,6'-diol

Description	Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
References	[1]. Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795. [2]. Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.

Hazard Codes	Xi