COX-2-IN-28

Modify Date: 2025-09-18 17:12:50

COX-2-IN-28 structure	Common Name	COX-2-IN-28
	CAS Number	2413565-18-9	Molecular Weight	581.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₇N₇S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of COX-2-IN-28

COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively[1].

Name	COX-2-IN-28

Description	COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:13.21 μM (IC50) COX-2:0.054 μM (IC50) 15-LOX:2.14 μM (IC50)
In Vitro	COX-2-IN-28 (compound 15c) shows significant COX-2 selectivity with an SI value of 244.63[1].
References	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Molecular Formula	C₃₀H₂₇N₇S₃
Molecular Weight	581.78

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