2417995-08-3
2417995-08-3 structure
- Name: COX-2-IN-23
- Chemical Name: COX-2-IN-23
- CAS Number: 2417995-08-3
- Molecular Formula: C24H25N5O3S2
- Molecular Weight: 495.62
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2022-09-04 16:30:44
- Modify Date: 2024-08-13 07:22:30
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COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.
| Name | COX-2-IN-23 |
|---|
| Description | COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity. |
|---|---|
| Related Catalog | |
| Target |
COX-2:0.28 μM (IC50) COX-1:20.14 μM (IC50) |
| In Vivo | COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1]. Animal Model: Mature male albino rats[1] Dosage: 9 mg/kg Administration: Intraperitoneal injection; 0, 1, 2, 3 and 4 hours. Result: Had similar ulcerogenic activity to celecoxib. |
| References |
| Molecular Formula | C24H25N5O3S2 |
|---|---|
| Molecular Weight | 495.62 |