PROTAC CYP1B1 degrader-1
Modify Date: 2024-01-12 23:16:22
PROTAC CYP1B1 degrader-1 structure
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Common Name | PROTAC CYP1B1 degrader-1 | ||
|---|---|---|---|---|
| CAS Number | 2411389-67-6 | Molecular Weight | 785.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H39N5O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC CYP1B1 degrader-1PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1]. |
| Name | PROTAC CYP1B1 degrader-1 |
|---|
| Description | PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C43H39N5O10 |
|---|---|
| Molecular Weight | 785.80 |
| InChIKey | MRMQVUIZIOZVSD-UHFFFAOYSA-N |
| SMILES | COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4cn(CCCCCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12 |