Nek2-IN-6

Modify Date: 2025-08-25 18:07:28

Nek2-IN-6 structure	Common Name	Nek2-IN-6
	CAS Number	2410376-96-2	Molecular Weight	666.71
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₃F₃N₆O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nek2-IN-6

Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor[1].

Name	Nek2-IN-6

Description	Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Nek2[1]
In Vitro	Nek2-IN-6 (Compound 28e) (0-30 μM, 72 h) inhibits tumor cells proliferation[1]. Cell Proliferation Assay[1] Cell Line: MGC-803, Hep-3B, BEL-7402, HCT-116 Concentration: 0-30 μM Incubation Time: 72 h Result: Inhibited cell proliferation with IC50s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.
References	[1]. Wang H, et al. Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115775.

Molecular Formula	C₃₃H₃₃F₃N₆O₄S
Molecular Weight	666.71

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