2378710-04-2

2378710-04-2 structure

Name: CDK7-IN-6
Chemical Name: CDK7-IN-6
CAS Number: 2378710-04-2
Molecular Formula: C₂₆H₃₄ClN₉O
Molecular Weight: 524.06
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-02-21 12:30:06
Modify Date: 2024-01-21 23:17:39
CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer[1].

Name	CDK7-IN-6

Description	CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK7:≤100 nM (IC50)
In Vitro	CDK7-IN-6 inhibits the viability of HCT116, H460, MV4-11, A2780, and OVCAR cells (IC50≤1 μM)[1].
References	[1]. Kiyean NAM, et al.Preparation of pyrazolotriazine and/or pyrazolopyrimidine derivatives as selective inhibitor of cyclin dependent kinase. WO2019197549 A1.

Molecular Formula	C₂₆H₃₄ClN₉O
Molecular Weight	524.06