p62-ZZ ligand YOK-1304
Modify Date: 2024-01-12 01:55:09
p62-ZZ ligand YOK-1304 structure
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Common Name | p62-ZZ ligand YOK-1304 | ||
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| CAS Number | 2409960-02-5 | Molecular Weight | 435.564 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H33NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of p62-ZZ ligand YOK-1304YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.AUTOphagy-TArgeting Chimera (AUTOTAC) is a general chemical tool and platform technology, which employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands.AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation. |
| Name | p62-ZZ ligand YOK-1304 |
|---|
| Description | YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.AUTOphagy-TArgeting Chimera (AUTOTAC) is a general chemical tool and platform technology, which employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands.AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation. |
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| References | 1. Chang Hoon Ji, et al. Nat Commun. 2022 Feb 16;13(1):904. |
| Molecular Formula | C27H33NO4 |
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| Molecular Weight | 435.564 |