2409960-02-5
2409960-02-5 structure
- Name: p62-ZZ ligand YOK-1304
- Chemical Name: p62-ZZ ligand YOK-1304
- CAS Number: 2409960-02-5
- Molecular Formula: C27H33NO4
- Molecular Weight: 435.564
- Create Date: 2022-07-01 14:29:41
- Modify Date: 2024-01-12 01:55:09
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YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.AUTOphagy-TArgeting Chimera (AUTOTAC) is a general chemical tool and platform technology, which employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands.AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation.
| Name | p62-ZZ ligand YOK-1304 |
|---|
| Description | YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.AUTOphagy-TArgeting Chimera (AUTOTAC) is a general chemical tool and platform technology, which employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands.AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation. |
|---|---|
| References | 1. Chang Hoon Ji, et al. Nat Commun. 2022 Feb 16;13(1):904. |
| Molecular Formula | C27H33NO4 |
|---|---|
| Molecular Weight | 435.564 |