IDO1/TDO-IN-1

Modify Date: 2025-09-12 14:38:17

IDO1/TDO-IN-1 structure	Common Name	IDO1/TDO-IN-1
	CAS Number	2379527-72-5	Molecular Weight	364.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IDO1/TDO-IN-1

IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

Name	IDO1/TDO-IN-1

Description	IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IDO1:0.23 μM (Ki) TDO:0.73 μM (Ki)
References	[1]. Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.

Molecular Formula	C₂₁H₁₆O₆
Molecular Weight	364.35
InChIKey	HBGFMECMJXIZLM-UHFFFAOYSA-N
SMILES	CC(=O)OCc1coc2c1C(=O)C(=O)c1c-2ccc2c1C=CC(=O)C2(C)C

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IDO1/TDO-IN-1

Use of IDO1/TDO-IN-1

Names

IDO1/TDO-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.