TMX-4100
Modify Date: 2025-08-27 18:18:51
TMX-4100 structure
|
Common Name | TMX-4100 | ||
|---|---|---|---|---|
| CAS Number | 2367619-63-2 | Molecular Weight | 262.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H10N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TMX-4100TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. |
| Name | TMX-4100 |
|---|
| Description | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE6D |
| In Vitro | TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1]. TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1]. TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1]. Western Blot Analysis[1] Cell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D. Western Blot Analysis[1] Cell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM; Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D with the DC50 value less than 200 nM. |
| References |
| Molecular Formula | C11H10N4O2S |
|---|---|
| Molecular Weight | 262.29 |
| InChIKey | PGEUBQZQGXWTFO-UHFFFAOYSA-N |
| SMILES | O=C1CCC(n2cc(-c3ccsc3)nn2)C(=O)N1 |