2418022-85-0

2418022-85-0 structure

2418022-85-0 structure

Name: TMX-2164
Chemical Name: TMX-2164
CAS Number: 2418022-85-0
Molecular Formula: C₂₅H₂₄ClFN₆O₆S
Molecular Weight: 591.01
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2022-11-15 19:23:19
Modify Date: 2024-01-10 20:12:48
TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].

Name	TMX-2164

Description	TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	IC50: 152 nM (BCL6)[1]
In Vitro	TMX-2164 (5 μM; 30 h; HEK293T-cells) displays sustained target engagement and to prolongs occupancy on BCL6 protein[1]. TMX-2164 (6.2 μM; 1, 3, and 5 d; SU-DHL-4 cells) exhibits single digit micromolar antiproliferative activity in SU-DHL-4 cells[1]. Cell Viability Assay[1] Cell Line: SU-DHL-4 cells Concentration: 6.2 μM Incubation Time: 1, 3, and 5 days Result: Inhibited cell growth with 5 days.
References	[1]. Teng M, et, al. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Apr 3;11(6):1269-1273.

Molecular Formula	C₂₅H₂₄ClFN₆O₆S
Molecular Weight	591.01