Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TMX-201
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: TMX-201
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1149339-78-5

1149339-78-5 structure

1149339-78-5 structure

Name: TMX-201
Chemical Name: TMX-201
CAS Number: 1149339-78-5
Molecular Formula: C₅₇H₉₃N₆O₁₂P
Molecular Weight: 1085.36
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2022-12-01 13:04:54
Modify Date: 2025-08-26 21:20:59
TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research[1].

Name	TMX-201

Description	TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
Target	TLR7
In Vitro	TMX-201 is more potent cytokine inducer than Imiquimod (HY-B0180) in both mouse and human mononuclear cells. TMX-201 shows less off-target binding compared to Imiquimod[1].
In Vivo	The maximum tolerated dose of TMX-201 by i.v. administration is 75 mg/kg[1]. TMX-201 (4mg/kg, IP) suppresses the growth of established subcutaneous B16 melanoma by 46%, without discernible adverse effects[1]. TMX-201 (IP or intra-tumor administration), in combination with anti-CTLA4 antibody, significantly suppressed lung metastasis formation in the 4T1 breast cancer model[1].
References	[1]. Dennis A. Carson, et al. Application of novel phospholipid conjugated Toll like receptor 7 ligands for cancer therapy by topical and systemic administration. Cancer Res 2014;74(19 Suppl): 2568.

Molecular Formula	C₅₇H₉₃N₆O₁₂P
Molecular Weight	1085.36

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