HaloPROTAC-E
Modify Date: 2025-08-28 19:41:44
HaloPROTAC-E structure
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Common Name | HaloPROTAC-E | ||
|---|---|---|---|---|
| CAS Number | 2365478-58-4 | Molecular Weight | 790.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H56ClN5O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HaloPROTAC-EHaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14). |
| Name | (2S,4R)-N-(2-(2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14). |
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| Related Catalog | |
| References |
| Molecular Formula | C39H56ClN5O8S |
|---|---|
| Molecular Weight | 790.41 |
| InChIKey | NJCGXLMTZGCSRS-JSWXEYCZSA-N |
| SMILES | Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)C2(C#N)CC2)C(C)(C)C)c(OCCOCCOCCOCCCCCCCl)c1 |
| MFCD32662642 |
| HaloPROTAC-E |