HaloPROTAC-E

Names

[ Name ]:
HaloPROTAC-E

[Synonym ]:
MFCD32662642
HaloPROTAC-E

Biological Activity

[Description]:

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> SGK

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14(5):882-892.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₅₆ClN₅O₈S

[ Molecular Weight ]:
790.41

Related Compounds

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