Aegeline

Modify Date: 2024-01-05 16:22:56

Aegeline structure	Common Name	Aegeline
	CAS Number	456-12-2	Molecular Weight	297.348
	Density	1.2±0.1 g/cm3	Boiling Point	567.7±50.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₉NO₃	Melting Point	180 °C
	MSDS	N/A	Flash Point	297.1±30.1 °C

Use of Aegeline

Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

Name	(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Synonym	More Synonyms

Description	Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Neurological Disease
In Vitro	Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein orBax-expressing cells[1]. Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2].
References	[1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [2]. Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24(3):359‐367.

Density	1.2±0.1 g/cm3
Boiling Point	567.7±50.0 °C at 760 mmHg
Melting Point	180 °C
Molecular Formula	C₁₈H₁₉NO₃
Molecular Weight	297.348
Flash Point	297.1±30.1 °C
Exact Mass	297.136505
PSA	62.05000
LogP	2.45
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.612
Storage condition	2-8°C

Hazard Codes	Xi
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

UNII:60T59LN3SG

Aegelin

(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylacrylamide

2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-

2-propenamide

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Aegeline
Price: ￥168.0/1g ￥98.0/250mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Aegeline
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Aegelin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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