Procyanidin B3

Modify Date: 2024-01-08 10:33:46

Procyanidin B3 Structure
Procyanidin B3 structure
 Common Name Procyanidin B3
CAS Number 23567-23-9 Molecular Weight 578.520
Density 1.7±0.1 g/cm3 Boiling Point 955.3±65.0 °C at 760 mmHg
Molecular Formula C30H26O12 Melting Point 218-219℃
MSDS N/A Flash Point 531.6±34.3 °C

 Use of Procyanidin B3


Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].

 Names

Name procyanidin B3
Synonym More Synonyms

 Procyanidin B3 Biological Activity

Description Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].
Related Catalog
Target

p300[1]
References

[1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 955.3±65.0 °C at 760 mmHg
Melting Point 218-219℃
Molecular Formula C30H26O12
Molecular Weight 578.520
Flash Point 531.6±34.3 °C
Exact Mass 578.142456
PSA 220.76000
LogP 0.30
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.803
Storage condition ?20°C

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36

 Synthetic Route

 Synonyms

Proanthocyanidin B3
Procyanidin B2
(2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol
(2R,3S)-2-(3,4-dihydroxyphenyl)-8-[(2R,3S,4S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
4,8"-Bi-[(+)-epicatechin]
Procyanidin B-3
Proanthocyanidin
UNII-L88HKE854X
2,3-trans-proanthocyanidin
[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-
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Chemsrc provides Procyanidin B3(CAS#:23567-23-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Procyanidin B3 are included as well.>> amp version: Procyanidin B3

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