Methyl 4-hydroxy-3-methoxycinnamate

Modify Date: 2025-08-27 11:38:45

Methyl 4-hydroxy-3-methoxycinnamate structure	Common Name	Methyl 4-hydroxy-3-methoxycinnamate
	CAS Number	2309-07-1	Molecular Weight	208.21
	Density	1.2±0.1 g/cm3	Boiling Point	338.1±27.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂O₄	Melting Point	62-65°C
	MSDS	N/A	Flash Point	130.4±17.2 °C

Use of Methyl 4-hydroxy-3-methoxycinnamate

Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].

Name	trans-methylferulate
Synonym	More Synonyms

Description	Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	p38
In Vitro	Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2]. Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2].
References	[1]. Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta. 2012 May;1822(5):748-52. [2]. Phuong NT, et al. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med. 2014 Sep;7S1:S327-31.

Density	1.2±0.1 g/cm3
Boiling Point	338.1±27.0 °C at 760 mmHg
Melting Point	62-65°C
Molecular Formula	C₁₁H₁₂O₄
Molecular Weight	208.21
Flash Point	130.4±17.2 °C
Exact Mass	208.073563
PSA	55.76000
LogP	1.40
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.575
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD9470000

CHEMICAL NAME :: Cinnamic acid, 4-hydroxy-3-methoxy-, methyl ester

CAS REGISTRY NUMBER :: 2309-07-1

BEILSTEIN REFERENCE NO. :: 2731141

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H12-O4

MOLECULAR WEIGHT :: 208.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1189 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,187,1987

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RTECS	GD9470000
HS Code	2918990090

Precursor 7
CAS#:67-56-1 Methanol CAS#:1135-24-6 ferulic acid CAS#:121-33-5 Vanillin CAS#:186581-53-3 diazomethane
CAS#:7664-93-9 Sulfuric acid CAS#:97-54-1 Isoeugenol,mixt... CAS#:292638-85-8 acrylic acid me...
DownStream 10
CAS#:3943-74-6 Methyl vanillate CAS#:121-33-5 Vanillin CAS#:56024-44-3 Methyl 3-(4-Hyd... CAS#:458-35-5 Coniferyl alcohol
CAS#:10231-47-7 3-(4-ethoxy-3-m... CAS#:1135-24-6 ferulic acid CAS#:5396-64-5 2-Propenoic aci... CAS#:2305-13-7 Hydroconiferyl ...
CAS#:5396-66-7 methyl 2,3-dibr... CAS#:57371-44-5 3-(4-(Benzyloxy...

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Ferulic acid methyl ester

Methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate

ferulic acid amide

Ferulasaeure-amid

2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-, methyl ester

Ferulamid

Methyl ferulate

methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

4-Hydroxy-3-methoxy-zimtsaeure-amid

Methyl 4-hydroxy-3-methoxycinnamate

4-Oxy-3-methoxy-zimtsaeure-amid

Ferulamide

4-hydroxy-3-methoxy-cinnamic acid amide

4-Hydroxy-3-Methoxycinnamide

methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

MFCD00017208

methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester, (2E)-

2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester (9CI)

CINNAMIC ACID,4-HYDROXY-3-METHOXY-,METHYL ESTER

CINNAMAMIDE,4-HYDROXY-3-METHOXY

methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Ferulic amide

feruloylamide

3-(4-Hydroxy-3-methoxyphenyl)-2-propenamide

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Methyl 4-hydroxy-3-methoxycinnamate

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