N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Modify Date: 2024-04-03 16:21:36

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine structure	Common Name	N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine
	CAS Number	2305416-07-1	Molecular Weight	366.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₂N₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Description	N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Molecular Formula	C₁₅H₂₂N₆O₅
Molecular Weight	366.37
InChIKey	LOSZXLFNDXRZQH-QKKNGTDUSA-N
SMILES	COC1C(O)C(CO)OC1n1cnc2c(=O)n(C)c(N=CN(C)C)nc21

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N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Use of N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Names

Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.