N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Names

[ CAS No. ]:
2305416-07-1

[ Name ]:
N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

Biological Activity

[Description]:

N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H22N6O5

[ Molecular Weight ]:
366.37

Related Compounds

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