L-AP3
Modify Date: 2024-01-31 12:59:31
L-AP3 structure
|
Common Name | L-AP3 | ||
|---|---|---|---|---|
| CAS Number | 23052-80-4 | Molecular Weight | 169.07 | |
| Density | 1.763 g/cm3 | Boiling Point | 481.6ºC at 760 mmHg | |
| Molecular Formula | C3H8NO5P | Melting Point | 227-229ºC | |
| MSDS | Chinese USA | Flash Point | 245.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of L-AP3L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1]. |
| Name | (2R)-2-amino-3-phosphonopropanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | L-AP3 inhibits D-phosphoserine and L-phosphoserine with Kis of 151 μM and 845 μM, respectively[1]. L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [3H]glutamate binding to mGlu3, receptors (Ki 125 μM)[1]. L-AP3 is a potent inhibitor of sodium-dependent L-[3H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1]. |
| In Vivo | L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1]. |
| References |
| Density | 1.763 g/cm3 |
|---|---|
| Boiling Point | 481.6ºC at 760 mmHg |
| Melting Point | 227-229ºC |
| Molecular Formula | C3H8NO5P |
| Molecular Weight | 169.07 |
| Flash Point | 245.1ºC |
| Exact Mass | 169.01400 |
| PSA | 130.66000 |
| Vapour Pressure | 1.34E-10mmHg at 25°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2931900090 |
| HS Code | 2931900090 |
|---|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
| (2S)-2-amino-3-phosphonopropionic acid |
| L(+)-2-Amino-3-phosphonopropionic acid |
| L(+)-2-Amino-3-phosphonopropionic acidL-AP3 |
| (R)-2-Amino-3-phosphonopropanoic acid |
| (R)-(+)-2-AMINO-3-PHOSPHONOPROPIONIC ACID |
| L-AP3 |
| (S)-(+)-2-amino-3-phosphonopropanoic acid |
| 3-PHOSPHONO-L-ALANINE |
| MFCD00083169 |
| Phosphonoalanine |
| (2R)-2-Amino-3-phosphonopropionic acid |
| L(+)-2-AMINO-3-PHOSPHONOPROPANOIC ACID |
| phosphoserine |