Izumerogant

Modify Date: 2024-04-06 17:56:48

Izumerogant Structure
Izumerogant structure
Common Name Izumerogant
CAS Number 2299252-72-3 Molecular Weight 495.86
Density N/A Boiling Point N/A
Molecular Formula C22H18ClF4N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Izumerogant


Izumerogant is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM[1][2].

 Names

Name Izumerogant

 Izumerogant Biological Activity

Description Izumerogant is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM[1][2].
Related Catalog
References

[1]. F Jakob, et al. Isoxazole-pyrazole derivatives and related compounds as IL-17 and IFN-γ inhibitors for treating autoimmune diseases and chronic inflammation: World Intellectual Property Organization, WO2019048541. 2019-03-14.

[2]. WHO Drug Information-World Health Organization (WHO).

 Chemical & Physical Properties

Molecular Formula C22H18ClF4N5O2
Molecular Weight 495.86